Description

The Core offers in vivo phenotyping of mice to comprehensively assess parameters of metabolism, cellular function, and signaling in tissues critical to and affected by diabetes. Many of these studies can be performed in conscious unrestrained mice using a dual catheter system. Affiliates can also utilize surgical services for continuous glucose monitor implant. The following measurements can be made: Hyperinsulinemic-euglycemic clamp; Intraperitoneal glucose, insulin, and pyruvate tolerance tests; Intravenous glucose tolerance test (including FSIVGTT); Oral glucose tolerance test; PET/CT imaging; Islet transplantation.

Key Words

Diabetes, Clamp, Glucose, Insulin, Mice, Seahorse, Mitochondria, Tolerance Test, Phenotyping, Metabolism, Islets, Perifusion, Assays, PET/CT Imaging, Hormone