Description

The University of Washington Mass Spectrometry Center (SOPMS), operated in the Department of Medicinal Chemistry, is a self-sustaining instrument laboratory providing a wide variety of mass spectral services to both the academic and the research community at large on a regulated recharge basis. The Center provides investigators with hands-on training in the use of and ready access to state-of-the-art instrumentation required in the sensitive and specific detection, identification, and quantification of materials encountered in biomedical and biopharmaceutical research. In addition, the Center provides contracted method-development services. Skilled staff members are available to train users in the theoretical and practical aspects of mass spectrometry and assist investigators in method development, assay validation, and data interpretation. Center personnel also collaborate with investigators to solve unique research problems requiring mass spectrometry and ancillary isolation and separation techniques. Bioanalytical capability of the center includes qualitative and quantitative analysis of compounds, liquid chromatographic-mass spectrometric (LC/MS) analysis of polar, thermally labile, and higher molecular weight materials. Quantification of materials from complex biological matrices, accurate mass measurement high-resolution mass spectral (HRMS) analysis, empirical formula determination of materials, and LC/MS analysis and peptide sequencing of protein digests are available.

Keywords

Mass Spectrometry, Liquid Chromatography, Orbitraps, Ion Mobility, UPLC, HDX, MS-Imaging, Proteomics, Method Development, Nanoflow, MALDI, Electrospray